Precision Prescribing in Autism Spectrum Disorder
Katelyn Rossow, MD
BACKGROUND: Children with autism spectrum disorder are commonly prescribed medications that affect mood and behavior in a non-standardized, trial and error fashion. These children are thought to have more side effects from these medications, but how frequent side effects are and what may be causing them is unknown.
GAP: This study will investigate how genetic factors including copy number variants and polygenic risk score for autism spectrum disorder may influence medication side effects.
HYPOTHESIS: Our overall hypothesis is that some genetic risk factors for autism spectrum disorder also lead to medication side effects.
METHODS: This study will at the biobank at Vanderbilt University Medical Center called BioVU. Methods will include a nested case-control study and a retrospective cohort study.
IMPACT: We hope to find genetic factors that can be used to predict which children with autism spectrum disorder will have side effects from certain medications. We plan to combine this information with other factors that are associated with side effects to help providers make safer medication choices for these children. Our ultimate goal is to improve the safety and efficacy of the medicines used to treat behavior and mood in children with autism spectrum disorder.