Thrasher Research Fund - Medical research grants to improve the lives of children

Project Details

Early Career

Status: Funded - Open

Coronary Flow Assessment by Ultrafast Ultrasound Doppler - Application in Pediatric Cardiology

Olivier Villemain, MD, PhD

Summary

BACKGROUND: Current non-invasive techniques do not allow to study myocardial perfusion in children while abnormalities in myocardial perfusion are thought to play an important role in the development of myocardial dysfunction in specific high-risk populations. Ultrafast Doppler imaging of the distal coronary bed could bridge this knowledge gap and initial proof-of-concept data suggest this technique has great potential to quantitatively assess myocardial perfusion GAP: This study aims to develop and optimize a quantitative technique for studying intramyocardial perfusion to be able to study the relationship between intramyocardial perfusion and function in newborns with critical heart disease. HYPOTHESIS: Coronary ultrafast Doppler angiography is feasible in normal infants and in newborns with congenital heart disease. The quantitative assessment of intramyocardial coronary flow is homogeneous in healthy newborns with changes occurring during the transitional circulation or for some congenital heart disease. METHODS: Prospective, observational, single center, open, non-controlled and non-randomized feasibility study. The study will include newborns < 1 month of age (total n = 80): 1) healthy controls (n=40); 2) transposition of great arteries (TGA) group (n=20); 3) hypoplastic left heart syndrome (HLHS) group (n=20). RESULTS: Pending IMPACT: To establish normal values for intramyocardial perfusion in infants during the first month of life. To evaluate intramyocardial perfusion in high-risk groups (HLHS, TGA) undergoing cardiac surgery. Website Link: https://lab.research.sickkids.ca/villemain/

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