Thrasher Research Fund - Medical research grants to improve the lives of children

Project Details

E.W. "Al" Thrasher

Status: Funded - Open

Effect of early-life nutrition and WASH interventions on the long-term health of Zimbabwean children

Andrew Prendergast, MA, DPhil, MRCPCH


BACKGROUND: Stunting affects 22% of children globally, and is associated with poorer performance in school, and lower adult earnings. There is an urgent need to evaluate whether early-life interventions for stunting improve school-age child function. GAP: Does improved infant and young child feeding (IYCF) and/or improved water, sanitation and hygiene (WASH) implemented during the first 1000 days result in improved cognition, physical and metabolic health at school age? HYPOTHESIS: At 7 years of age: i) Children randomized to early-life IYCF will have improved cognition and physical function, with no increase in adiposity, compared to children not receiving IYCF; and ii) Children randomized to WASH will have similar cognition and physical function, compared to children not receiving WASH. METHODS: 1000 children who were born in 2013-2016 and participated in the Sanitation Hygiene Infant Nutrition Efficacy trial in rural Zimbabwe (NCT01824940) will be assessed at 7 years of age for: i) Neurodevelopment: cognition, memory, spatial ability, reasoning, reading, literacy, attention, and socio-emotional behavior; ii) Physical health: hand/trunk muscle strength, exercise capacity, blood pressure and hemoglobin; iii) Growth and metabolic health: anthropometry, and body composition. The effect of IYCF and WASH on each outcome will be assessed by intention-to-treat analysis, capitalizing on the factorial trial design. RESULTS: Pending. IMPACT: This study will provide crucial evidence of whether early-life nutrition and WASH interventions have tangible benefits for long-term cognitive and functional performance without increasing metabolic risk. This has enormous potential impact for programs considering the global burden of stunting and the need for evidence-based interventions with long-term impact.

Supervising Institution:
Zvitambo Institute for Maternal & Child Health Research

Project Location:
United Kingdom, Zimbabwe

Award Amount: