Project Details

Early Career

Status: Funded - Open

STewardship for Acute Respiratory Illness (STAR): Expanding Access to Rapid Biomarker Testing

Emily Ciccone, MD, MHS


BACKGROUND: A key driver of global antimicrobial resistance is the inappropriate use of antibiotics, which are frequently prescribed to treat pediatric fever in resource-limited settings. However, ample data suggests that a large proportion of febrile illnesses, particularly those with respiratory symptoms, are caused by self-limited viral infections that do not require antibiotic therapy. GAP: There is an urgent need to improve the case management of pediatric acute respiratory illness (ARI) by non-physician providers, including community health workers (CHW), to whom the majority of children first present for care in rural, sub-Saharan Africa. HYPOTHESIS: The overarching scientific goal of this project is to demonstrate the feasibility and preliminary effectiveness of employing a rapid, point-of-care test for the clinical biomarker, C-reactive protein (CRP), to guide antibiotic treatment decisions by CHW for pediatric, malaria-negative, febrile ARI in rural Uganda. Our hypothesis is that we can safely reduce the proportion of children prescribed antibiotics by equipping CHW with these rapid diagnostic tests (RDT). METHODS: We will first compare the accuracy, cost, and ease-of-use of three CRP RDTs. After selecting the best-performing RDT, we will conduct a pilot study of its use to determine to whom antibiotics will be administered among children with malaria-negative, febrile ARI presenting to CHW for evaluation. RESULTS: Pending IMPACT: To our knowledge, this would be the first study to equip CHW with an RDT other than the malaria RDT and evaluate its impact on antimicrobial use. Given the vast burden of pediatric acute respiratory illness and expanding role CHW are playing in the initial care of children, our results could have a significant impact on global antibiotic use. Optional/Additional Comments: This work will be conducted in collaboration with Dr. Edgar Mulogo, Associate Professor and Chair of the Department of Community Health at the Mbarara University of Science and Technology in Mbarara, Uganda.