Project Details

Early Career

Status: Funded - Open

Impact of micronutrient powder on thiamin, folate and vitamin B12 status in children in rural Laos

Guy-Marino Hinnouho, MD, PhD


BACKGROUND: Thiamin, folate and vitamin B12 deficiencies can lead to growth and mental impairments, cognitive delays, neural tube defects and increased morbidity and mortality in young children.

GAP: The efficacy of micronutrients powder (MNP) interventions in improving iron, zinc and vitamin A status has been clearly demonstrated. However, limited data are available regarding the effect of MNP supplementation on thiamin, folate and vitamin B12 status in young children

HYPOTHESIS: We hypothesized that after 36 weeks of intervention, children in the MNP group will have higher thiamin, folate and vitamin B12 levels and lower rates of micronutrient deficiencies compared to children in placebo group, and that the prevalence of each micronutrient deficiency will be greater than 0% and children at higher risk of deficiency will have lower socio-economic status, inadequate feeding practices and growth impairment.

METHODS: This study is an add-on study to an ongoing randomized double-blind controlled community-based trial which will assess the impact of MNP supplementation on thiamin, folate and vitamin B12 status; children 6-23 months of age will be randomized to receive: 1) MNP (0.5 mg of thiamin, 150 μg of folic acid and 0.9 μg of vitamin B12 along with other micronutrients) and 2) placebo powder (no micronutrients) for 36 weeks.

RESULTS: Pending.

IMPACT: The impact assessment of MNP supplementation on children’s micronutrient status will provide relevant information on a possible intervention strategy to prevent thiamin, folate and vitamin B12 deficiencies. This research will help guide the design of national and sub-national MNP programs in low-income countries.

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