Project Details

E.W. "Al" Thrasher

Status: Funded - Open

Long-term effects of umbilical cord milking vs delayed cord clamping in preterm infants

Anup Katheria, M.D.


BACKGROUND: Very preterm infants born less than 32 weeks have the highest risk of neurodevelopmental impairment. Affecting approximately 450,000 babies annually in America, with more than 15 million worldwide, preterm infants are 22 times more likely to develop lasting neurodevelopmental disabilities including cerebral palsy and vision and hearing loss.

GAP: While American Committee on Obstetrics and Gynecology has only recommended delayed cord clamping (DCC), not cord milking, for premature babies, we demonstrated umbilical cord milking (UCM) improves organ blood flow and perfusion more efficiently in preterm infants delivered by Caesarean section than DCC.

HYPOTHESIS: We hypothesize that very preterm infants born less than 32 weeks and delivered by C/S in the UCM group will have better motor and cognitive function at 22 to 26 months CGA when compared with preterm infants in the DCC group.

METHODS: The study population consists of premature babies who were enrolled in the PREMOD (NCT01866982) study and who have reached approximately 22 to 26 months corrected gestational age.

RESULTS: We are currently conducting 22-26 month neurodevelopmental follow-up on subjects from the original trial.

IMPACT: This study will establish a scientific basis for the recommendation for umbilical cord management in very preterm infants delivered by C/S.

Supervising Institution:
Sharp Mary Birch Hospital for Women & Newborns

Project Location:
California, California

Award Amount: