Status: Funded - Open
Immunology of group A Streptococcus tonsillitis
Jennifer Dan, MD, PHD
BACKGROUND: Recurrent tonsillitis is a widespread pediatric problem with most cases attributed to Group A Streptococcus (GAS). Children who present with strep throat require prompt antibiotic treatment to prevent the development of acute rheumatic fever and rheumatic heart disease.
GAP: It is still unclear why some children get recurrent tonsillitis.
HYPOTHESIS: Preliminary data from our cohort suggests that children with recurrent tonsillitis have smaller germinal centers with deficiencies in their B and T cells. We hypothesize that children with recurrent tonsillitis have an immunosusceptibility to GAS.
METHODS: We have developed cohort of children who have undergone tonsillectomies for recurrent tonsillitis and a control group. We will quantify T and B cell populations within the tonsils to address why these children have a predisposition to GAS.
IMPACT: By delineating the immunological differences in our cohort, we hope to identify what makes these individuals susceptible to GAS as this will for earlier screening for at risk children.
Website Link: http://www.liai.org/pages/faculty-crotty