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Project Details

Early Career

Status: Funded - Open


Prevalence of maternal group B Streptococcal colonization in India

Manu Chaudhary, M.D.

Summary

BACKGROUND: The burden of neonatal group B streptococcal (GBS) disease is substantial but gaps remain in defining its full global impact.  India has the highest number of neonatal deaths in the world, but the proportion attributable to group B Streptococcus is not known.

GAP: GBS colonization rates in pregnant women range from 20% to 35% and 1% to 2% of infants born to GBS-colonized women develop early-onset GBS disease unless vertical transmission is interrupted.  Existing studies suggest a low GBS colonization prevalence in India but these have not employed optimal methods for isolation, including choice of sampling sites, use of selective media and adequate sample size. 

HYPOTHESIS: Use of optimal methods will reveal that 20% to 35% of pregnant women in India have positive GBS cultures from the vagina or rectum during the last trimester of pregnancy or at admission for delivery.

METHODS: A maternal colonization prevalence study at the Dr. Ram Manohar Lohia Hospital in Delhi will be performed to obtain lower vaginal and rectal swabs from 300 women in their last trimester of pregnancy.  Swabs will be processed optimally for GBS isolation and GBS isolates will be further characterized by serotype and genotype.

RESULTS: Pending

IMPACT:  Accurate assessment of the GBS colonization rate in a cohort of pregnant women will allow projection of the burden of early-onset GBS disease in India, will inform the potential impact of intrapartum antibiotic prophylaxis to prevent early-onset GBS disease and will contribute to vaccine development globally by revealing GBS types prevalent in India.










Supervising Institution:
Texas Children's Hospital

Mentor(s):
Morven Edwards

Project Location:
United States, India

Award Amount:
$26,750

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