Project Details

Early Career

Status: Funded - Open

Investigation of copy number variation in the placentas of pregnancies with intrauterine growth restriction

Ryan Yuen, Ph.D.


BACKGROUND:  Intrauterine growth restriction (IUGR) is a condition in which the baby has a birth weight lower than 10th percentile for gestational age, and is often a precursor of other long-term diseases later in children and adult life.

GAP:  As much as 20% of IUGR can be explained by genetic defects, but the involvement of copy number variation (CNV) has never been investigated.

HYPOTHESIS:  Rare CNV disrupting important genes can be found in the placentas of pregnancies with IUGR.

METHODS:  CNV detection will be performed on a high-resolution microarray platform from a Canadian cohort of IUGR placentas without known chromosomal abnormalities.

RESULTS:  Pending

IMPACT:  The findings of this project will allow early genetic diagnosis for IUGR using microarray without relying on the fetal and placental morphologies.

Supervising Institution:
The Hospital for Sick Children

Stephen Scherer

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