Status: Funded - Open
Investigation of copy number variation in the placentas of pregnancies with intrauterine growth restriction
Ryan Yuen, Ph.D.
BACKGROUND: Intrauterine growth restriction (IUGR) is a condition in which the baby has a birth weight lower than 10th percentile for gestational age, and is often a precursor of other long-term diseases later in children and adult life.
GAP: As much as 20% of IUGR can be explained by genetic defects, but the involvement of copy number variation (CNV) has never been investigated.
HYPOTHESIS: Rare CNV disrupting important genes can be found in the placentas of pregnancies with IUGR.
METHODS: CNV detection will be performed on a high-resolution microarray platform from a Canadian cohort of IUGR placentas without known chromosomal abnormalities.
IMPACT: The findings of this project will allow early genetic diagnosis for IUGR using microarray without relying on the fetal and placental morphologies.