Project Details

Early Career

Status: Funded - Open

Feasibility trial of invasive infection prevention in children with sickle cell disease in Africa

Elizabeth Van Dyne, M.D.


BACKGROUND: Sickle cell disease (SCD) is the most common hematologic inherited disorder worldwide and in the United States life expectancy has increased due to early diagnostic screening for newborns, infection prevention through penicillin prophylaxis and vaccines, and supportive care programs. It is estimated that 200,000 to 300,000 children are born per year with SCD in Africa. The majority of the world’s SCD burden is in Sub-Saharan Africa, a location where many children with SCD die due to lack of diagnosis and early interventions.

GAP: This study will address research gaps in feasibility of diagnosis, infection prevention, and comprehensive care programs for children with SCD in Malawi. 

HYPOTHESIS: Diagnosis of SCD and early intervention through penicillin prophylaxis and education will decrease pneumococcal septicemia in children with SCD in Malawi.

METHODS: Introduce a cost-effective program and collaborative approach to diagnose children with SCD, prevent invasive pneumococcal disease, and offer comprehensive care in Malawi.

RESULTS: Pending

IMPACT: Simple cost-effective interventions, involving early testing and comprehensive care, can decrease mortality in patients with SCD. This comprehensive approach would add to research and ultimately to the survival and health of children with SCD.

Supervising Institution:
University of California, Los Angeles

Theodore Moore

Project Location:

Award Amount: