Status: Funded - Open
Feasibility of a computerized neurocognitive intervention program in the early post-transplant setting
Susan Hiniker, M.D.
BACKGROUND: Children undergoing stem cell transplantation (SCT) as curative therapy for acute lymphoblastic leukemia (ALL) are at risk for neurocognitive deficits which may be potentially ameliorated through prospective identification of at-risk individuals and early intervention. Cognitive intervention programs have shown promise in pilot studies of pediatric cancer survivors, but in-person programs are difficult to implement and have not yet been evaluated in the immediate post-SCT setting.
GAP: This study will seek to identify the risk factors associated with poor neurocognitive outcomes after SCT, and will test the feasibility of an easily-implementable tablet-based early neurocognitive intervention program.
HYPOTHESIS: We hypothesize that children treated with SCT for ALL experience significant long-term neurocognitive deficits, and that there are identifiable factors associated with poor post-transplant neurocognitive outcome. We further hypothesize that early neurocognitive intervention using a novel computerized cognitive intervention program in the immediate post-SCT setting is feasible and is associated with improved performance on post-SCT neurocognitive testing.
METHODS: This study is a one-arm prospective pilot study of an anticipated 35 pediatric patients undergoing SCT, evaluating the feasibility and efficacy of a tablet-based cognitive intervention program in the immediate post-SCT setting.
IMPACT: If this approach proves feasible in this pilot study, it could be tested on a larger scale in a potentially practice-changing randomized controlled trial, and this approach could also be tested in other diseases and therapies assocated with adverse neurocognitive effects.