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Project Details

Early Career

Status: Funded - Open


Feasibility of a computerized neurocognitive intervention program in the early post-transplant setting

Susan Hiniker, M.D.

Summary

BACKGROUND:  Children undergoing stem cell transplantation (SCT) as curative therapy for acute lymphoblastic leukemia (ALL) are at risk for neurocognitive deficits which may be potentially ameliorated through prospective identification of at-risk individuals and early intervention. Cognitive intervention programs have shown promise in pilot studies of pediatric cancer survivors, but in-person programs are difficult to implement and have not yet been evaluated in the immediate post-SCT setting.

GAP:  This study will seek to identify the risk factors associated with poor neurocognitive outcomes after SCT, and will test the feasibility of an easily-implementable tablet-based early neurocognitive intervention program.

HYPOTHESIS:  We hypothesize that children treated with SCT for ALL experience significant long-term neurocognitive deficits, and that there are identifiable factors associated with poor post-transplant neurocognitive outcome. We further hypothesize that early neurocognitive intervention using a novel computerized cognitive intervention program in the immediate post-SCT setting is feasible and is associated with improved performance on post-SCT neurocognitive testing.

METHODS:  This study is a one-arm prospective pilot study of an anticipated 35 pediatric patients undergoing SCT, evaluating the feasibility and efficacy of a tablet-based cognitive intervention program in the immediate post-SCT setting.

RESULTS:  Pending

IMPACT:  If this approach proves feasible in this pilot study, it could be tested on a larger scale in a potentially practice-changing randomized controlled trial, and this approach could also be tested in other diseases and therapies assocated with adverse neurocognitive effects.










Supervising Institution:
Stanford University

Mentor(s):
Sarah Donaldson

Project Location:
California

Award Amount:
$26,750

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