Project Details

Early Career

Status: Funded - Open

Intramuscular epinephrine as an adjunctive treatment for severe pediatric asthma exacerbation

Kerry Caperell, M.D.


BACKGROUND:  Asthma is the most common chronic disease of childhood.  Severe asthma exacerbations are characterized by difficulty breathing and can be life-threatening.

GAP: This study seeks to identify a therapy for severe asthma exacerbations that can be added to conventional therapies to enable these children to breathe better more quickly.

HYPOTHESIS: Children with asthma exacerbation who receive intramuscular epinephrine will have more rapid resolution of their symptoms compared to those who don’t.

METHODS: Children with severe asthma exacerbation will be randomized to receive either a single dose of intramuscular epinephrine or no treatment at all.  The two groups will be compared based on their asthma symptoms and other parameters at various time points. 

RESULTS: Pending

DISCUSSION: If the therapy is effective, it has the potential to enable children to breathe easily more quickly than current therapeutic regimens.  It may reduce admission rates, intensive care utilization rates, and emergency department lengths of stay.

Drug Therapy, Asthma, Treatment, Human, Randomized Clinical Trial

Supervising Institution:
University of Louisville

Michelle Stevenson

Project Location:

Award Amount: