E.W. "Al" Thrasher
Status: Funded - Open
ASL perfusion MRI in pediatric brain tumor
Michael Fisher, M.D.
BACKGROUND: Although survival rates of children with brain tumors have improved over the past decade, brain tumors remain the leading cause of cancer death in children.
GAP: The accurate diagnosis of brain tumors relies on analysis of tissue samples taken during surgery (biopsy); however, some tumors cannot be biopsied because of their location. In addition, present radiologic techniques cannot reliably predict tumor behavior or outcome. Measures of tumor blood flow may help differentiate the grade (aggressiveness) of a tumor as well as its behavior. Arterial Spin Labeling (ASL) is a new, noninvasive MRI technique that measures blood flow to tumors.
HYPOTHESIS: The overall goal of this project is to evaluate ASL MRI for grading and predicting the behavior of childhood brain tumors. We hypothesize that tumors with high blood flow are more likely to be malignant and more likely to grow over time. We also hypothesize that ASL can predict tumor which tumors are likely to respond to therapy
METHODS: About 160 pediatric subjects with brain tumors will be recruited from the Children’s Hospital of Philadelphia during this study. These subjects will undergo an initial MRI scan prior to treatments. Follow-up MRI scans will be scheduled regularly for at least one year. ASL blood flow imaging results will be compared with biopsy results and tumor size measured on conventional MR images.
DISCUSSION: This project is expected to develop a reliable clinical tool for planning and monitoring therapy of pediatric brain tumors.
Cancer, Neurology, Magnetic Resonance Imaging, Prospective Cohort, Diagnosis, Human